150 badań naukowych o kolagenie i składnikach wspierających jego tworzenie – fundament Ysto

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LISTA BADAŃ

Oto lista 150 badań, które dokładnie przeanalizowaliśmy, by skomponować formułę kolagenów do picia Ysto. Większość stanowi zbiór aktualnej wiedzy na temat działania suplementacji peptydów kolagenowych. Pozostałe to badania o działaniu prourodowym różnych składników, które znajdziesz w naszych suplementach kolagenowych.

1 THE EFFECTS OF COLLAGEN PEPTIDE SUPPLEMENTATION ON BODY COMPOSITION, COLLAGEN SYNTHESIS, AND RECOVERY FROM JOINT INJURY AND EXERCISE A SYSTEMATIC: REVIEW

Khatri M, Naughton RJ, Clifford T, Harper LD, Corr L. The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. Amino Acids. 2021 Oct;53(10):1493-1506. doi: 10.1007/s00726-021-03072-x. Epub 2021 Sep 7. PMID: 34491424; PMCID: PMC8521576.

2 AN OVERVIEW OF THE BENEFICIAL EFFECTS OF HYDROLYSED COLLAGEN AS A NUTRACEUTICAL ON SKIN PROPERTIES SCIENTIFIC BACKGROUND AND CLINICAL STUDIES

SIBILLA, Sara, et al. An overview of the beneficial effects of hydrolysed collagen as a nutraceutical on skin properties: Scientific background and clinical studies. The Open Nutraceuticals Journal, 2015, 8.1.

Fakt nr 3: Organizm traci zdolności do uzupełniania kolagenu. Aż o ok. 1,5% rocznie!

Fakt nr 5: Między 25. a 50. rokiem życia ilość kwasu hialuronowego w skórze może obniżyć się o połowę

Fakt nr 6: Można aktywować komórki produkujące kolagen, elastynę i kwas hialuronowy w skórze

Fakt nr 7: Kolagen hydrolizowany w formie suplementu wchłania się lepiej niż kolagen w jedzeniu

Fakt nr 10: Hydrolizowane peptydy kolagenu wpływają na wygląd skóry dzięki 4. głównym mechanizmom

3 OZNACZANIE ZAWARTOŚCI HYDROKSYPROLINY W HANDLOWYCH PREPARATACH KOLAGENOWYCH METODĄ SPEKTROFOTOMETRYCZNĄ

Gendaszewska, D. Oznaczanie zawartości hydroksyproliny w handlowych preparatach kolagenowych metodą spektrofotometryczną. Technologia i Jakość Wyrobów. 2017, 62, s. 141–148.

Fakt nr 31: Dokładne oznaczenie aminokwasów w kolagenie jest możliwe i używane do badania jakości surowca kolagenowego

Fakt nr 53: Hydroksyprolina jako biomarker spożycia kolagenu

4 HYDROLYZED COLLAGEN—SOURCES AND APPLICATIONS

León-López A, Morales-Peñaloza A, Martínez-Juárez VM, Vargas-Torres A, Zeugolis DI, Aguirre-Álvarez G. Hydrolyzed Collagen-Sources and Applications. Molecules. 2019 Nov 7;24(22):4031. doi: 10.3390/molecules24224031. PMID: 31703345; PMCID: PMC6891674.

Fakt nr 7: Kolagen hydrolizowany w formie suplementu wchłania się lepiej niż kolagen w jedzeniu

Fakt nr 8: Hydrolizat kolagenu i żelatyna to nie to samo

5 COLLAGEN HYDROLYSATE FOR THE TREATMENT OF OSTEOARTHRITIS AND OTHER JOINT DISORDERS: A REVIEW OF THE LITERATURE

Bello AE, Oesser S. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Curr Med Res Opin. 2006 Nov;22(11):2221-32. doi: 10.1185/030079906X148373. PMID: 17076983.

6 EFFECT OF COLLAGEN SUPPLEMENTATION ON OSTEOARTHRITIS SYMPTOMS: A META-ANALYSIS OF RANDOMIZED PLACEBO-CONTROLLED TRIALS

García-Coronado JM, Martínez-Olvera L, Elizondo-Omaña RE, Acosta-Olivo CA, Vilchez-Cavazos F, Simental-Mendía LE, Simental-Mendía M. Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials. Int Orthop. 2019 Mar;43(3):531-538. doi: 10.1007/s00264-018-4211-5. Epub 2018 Oct 27. PMID: 30368550.

7 ULTRASONIC IRRADIATION IN THE ENZYMATIC EXTRACTION OF COLLAGEN. ULTRASON. SONOCHEMISTRY

Li D., Mu C., Cai S., Lin W. Ultrasonic irradiation in the enzymatic extraction of collagen. Ultrason. Sonochemistry. 2009;16:605–609.

8 ANTIMICROBIAL AND RADICAL SCAVENGING PROPERTIES OF BOVINE COLLAGEN HYDROLYSATES PRODUCED BY PENICILLIUM AURANTIOGRISEUM

Lima CA, Campos JF, Filho JL, Converti A, da Cunha MG, Porto AL. Antimicrobial and radical scavenging properties of bovine collagen hydrolysates produced by Penicillium aurantiogriseum URM 4622 collagenase. J Food Sci Technol. 2015 Jul;52(7):4459-66. doi: 10.1007/s13197-014-1463-y. Epub 2014 Jul 6. PMID: 26139912; PMCID: PMC4486589.

Fakt nr 32: Kolagen rybi różni się od kolagenu wołowego i wieprzowego

9 ORAL INGESTION OF COLLAGEN HYDROLYSATE LEADS TO THE TRANSPORTATION OF HIGHLY CONCENTRATED GLY-PRO-HYP AND ITS HYDROLYZED FORM OF PROHYP INTO THE BLOODSTREAM AND SKIN

Yazaki M, Ito Y, Yamada M, Goulas S, Teramoto S, Nakaya MA, Ohno S, Yamaguchi K. Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin. J Agric Food Chem. 2017 Mar 22;65(11):2315-2322. doi: 10.1021/acs.jafc.6b05679. Epub 2017 Mar 8. PMID: 28244315.

Fakt nr 7: Kolagen hydrolizowany w formie suplementu wchłania się lepiej niż kolagen w jedzeniu

10 TOPICAL APPLICATION AND ORAL SUPPLEMENTATION OF PEPTIDES IN THE IMPROVEMENT OF SKIN VISCOELASTICITY AND DENSITY

Maia Campos P.M., Melo M.O., Siqueira César F.C. Topical application and oral supplementation of peptides in the improvement of skin viscoelasticity and density. J. Cosmet. Dermatol. 2019

Fakt nr 10: Hydrolizowane peptydy kolagenu wpływają na wygląd skóry dzięki 4. głównym mechanizmom

11 FUNCTIONAL AND BIOACTIVE PROPERTIES OF COLLAGEN AND GELATIN FROM ALTERNATIVE SOURCES: A REVIEW

Gómez-Guillén M.C., Giménez B., López-Caballero M.E., Montero M.P. Functional and bioactive properties of collagen and gelatin from alternative sources: A review. Food Hydrocoll. 2011;25:1813–1827.

Fakt nr 8: Hydrolizat kolagenu i żelatyna to nie to samo

12 IMPROVEMENT OF SKIN CONDITION ON SKIN MOISTURE AND ANTI-MELANOGENESIS BY COLLAGEN PEPTIDES FROM MILKFISH (CHANOS CHANOS) SCALES

CHEN, Yu-Pei, et al. Improvement of skin condition on skin moisture and anti-melanogenesis by collagen peptides from milkfish (Chanos chanos) scales. In: IOP Conference Series: Materials Science and Engineering. IOP Publishing, 2018. p. 022067.

Fakt nr 10: Hydrolizowane peptydy kolagenu wpływają na wygląd skóry dzięki 4. głównym mechanizmom

Fakt nr 32: Kolagen rybi różni się od kolagenu wołowego i wieprzowego

13 EFFECTS OF DIETARY SUPPLEMENTATION WITH FISH SCALES-DERIVE COLLAGEN PEPTIDES ON SKIN PARAMETERS AND CONDITION: A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND STUDY

KOIZUMI, Seiko, et al. Effects of dietary supplementation with fish scales-derived collagen peptides on skin parameters and condition: A randomized, placebo-controlled, double-blind study. International Journal of Peptide Research and Therapeutics, 2018, 24: 397-402.

Fakt nr 10: Hydrolizowane peptydy kolagenu wpływają na wygląd skóry dzięki 4. głównym mechanizmom

14 A COLLAGEN SUPPLEMENT IMPROVES SKIN HYDRATION, ELASTICITY, ROUGHNESS, AND DENSITY: RESULTS OF A RANDOMIZED, PLACEBO-CONTROLLED, BLIND STUDY

Bolke L, Schlippe G, Gerß J, Voss W. A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study. Nutrients. 2019 Oct 17;11(10):2494. doi: 10.3390/nu11102494. PMID: 31627309; PMCID: PMC6835901.        

Fakt nr 10: Hydrolizowane peptydy kolagenu wpływają na wygląd skóry dzięki 4. głównym mechanizmom   

Fakt nr 28: Skuteczność hydrolizatu kolagenu jest potwierdzona badaniami klinicznymi, skuteczność liofilizatu kolagenu nie jest potwierdzona

15 MARINE COLLAGEN PEPTIDE ISOLATED FROM CHUM SALMON (ONCORHYNCHUS KETA) SKIN FACILITATES LEARNING AND MEMORY IN AGED C57BL/6J MICE

Pei X., Yang R., Zhang Z., Gao L., Wang J., Xu Y., Zhao M., Han X., Liu Z., Li Y. Peptyd kolagenu morskiego wyizolowany z łososia Chum (Oncorhynchus keta) ułatwia uczenie się i pamięć u starszych myszy C57BL/6J. Chemia spożywcza. 2010; 118 :333–340. doi: 10.1016/j.foodchem.2009.04.120.

16 A RANDOMIZED CONTROLLED TRIAL ON THE EFFICACY AND SAFETY OF A FOOD INGREDIENT, COLLAGEN HYDROLYSATE, FOR IMPROVING JOINT COMFORT

Benito-Ruiz P, Camacho-Zambrano MM, Carrillo-Arcentales JN, Mestanza-Peralta MA, Vallejo-Flores CA, Vargas-López SV, Villacís-Tamayo RA, Zurita-Gavilanes LA. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. Int J Food Sci Nutr. 2009;60 Suppl 2:99-113. doi: 10.1080/09637480802498820. Epub 2009 Feb 11. PMID: 19212858.

17 EFFICACY AND TOLERABILITY OF AN UNDENATURED TYPE II COLLAGEN SUPPLEMENT IN MODULATING KNEE OSTEOARTHRITIS SYMPTOMS: A MULTICENTER RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J. 2016 Jan 29;15:14. doi: 10.1186/s12937-016-0130-8. PMID: 26822714; PMCID: PMC4731911.

18 ROLE OF COLLAGEN HYDROLYSATE IN BONE AND JOINT DISEASE

Moskowitz RW. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum. 2000 Oct;30(2):87-99. doi: 10.1053/sarh.2000.9622. PMID: 11071580.

19 ANTIOXIDANT AND ANTIMICROBIAL PEPTIDE FRACTIONS FROM SQUID AND TUNA SKIN GELATIN

GUILLÉN, Gómez, et al. Antioxidant and antimicrobial peptide fractions from squid and tuna skin gelatin. 2010.

Fakt nr 25: Typ suplementowanego kolagenu ma mały wpływ na rezultaty suplementacji

Fakt nr 52: Rodzaj i jakość hydrolizy są kluczowe dla skuteczności i właściwości kolagenu

20 THE EFFECT OF PACIFIC COD (GADUS MACROCEPHALUS) SKIN GELATIN POLYPEPTIDES ON UV RADIATION-INDUCED SKIN PHOTOAGING IN ICR MICE

HOU, Hu, et al. The effect of pacific cod (Gadus macrocephalus) skin gelatin polypeptides on UV radiation-induced skin photoaging in ICR mice. Food chemistry, 2009, 115.3: 945-950.

21 EFFECT OF COLLAGEN HYDROLYSATES FROM SALMON AND TROUT SKINS ON THE LIPID PROFILE IN RATS

Saito M, Kiyose C, Higuchi T, Uchida N, Suzuki H. Effect of collagen hydrolysates from salmon and trout skins on the lipid profile in rats. J Agric Food Chem. 2009 Nov 11;57(21):10477-82. doi: 10.1021/jf902355m. PMID: 19831419.

22 EFFECT OF DIETARY SUPPLEMENTATION WITH COLLAGEN HYDROLYSATES ON BONE METABOLISM OF POSTMENOPAUSAL WOMEN WITH LOW MINERAL DENSITY

Cúneo F, Costa-Paiva L, Pinto-Neto AM, Morais SS, Amaya-Farfan J. Effect of dietary supplementation with collagen hydrolysates on bone metabolism of postmenopausal women with low mineral density. Maturitas. 2010 Mar;65(3):253-7. doi: 10.1016/j.maturitas.2009.10.002. Epub 2009 Nov 4. PMID: 19892499.

23 ISOLATION AND CHARACTERIZATION OF ANTIOXIDATIVE PEPTIDES FROM GELATIN HYDROLYSATE OF ALASKA POLLACK SKIN

Kim SK, Kim YT, Byun HG, Nam KS, Joo DS, Shahidi F. Isolation and characterization of antioxidative peptides from gelatin hydrolysate of Alaska pollack skin. J Agric Food Chem. 2001 Apr;49(4):1984-9. doi: 10.1021/jf000494j. PMID: 11308357.

Fakt nr 43: Antyoksydacyjny potencjał hydrolizatu kolagenu rybiego

24 ANTIOXIDANT PROPERTIES OF A RADICAL-SCAVENGING PEPTIDE PURIFIED FROM ENZYMATICALLY PREPARED FISH SKIN GELATIN HYDROLYSATE

Mendis E, Rajapakse N, Kim SK. Antioxidant properties of a radical-scavenging peptide purified from enzymatically prepared fish skin gelatin hydrolysate. J Agric Food Chem. 2005 Feb 9;53(3):581-7. doi: 10.1021/jf048877v. PMID: 15686405.

Fakt nr 43: Antyoksydacyjny potencjał hydrolizatu kolagenu rybiego

25 PURIFICATION AND CHARACTERIZATION OF ANGIOTENSIN I CONVERTING ENZYME (ACE) INHIBITORY PEPTIDES FROM ALASKA POLLACK (THERAGRA CHALCOGRAMMA) SKIN

BYUN, Hee-Guk; KIM, Se-Kwon. Purification and characterization of angiotensin I converting enzyme (ACE) inhibitory peptides from Alaska pollack (Theragra chalcogramma) skin. Process Biochemistry, 2001, 36.12: 1155-1162.

Fakt nr 32: Kolagen rybi różni się od kolagenu wołowego i wieprzowego

26 ANTIOXIDATIVE ACTIVITIES AND ANGIOTENSIN I-CONVERTING ENZYME INHIBITION OF EXTRACTS PREPARED FROM CHUM SALMON (ONCORHYNCHUS KETA) CARTILAGE AND SKIN

NAGAI, Takeshi, et al. Antioxidative activities and angiotensin I-converting enzyme inhibition of extracts prepared from chum salmon (Oncorhynchus keta) cartilage and skin. International Journal of Food Properties, 2006, 9.4: 813-822.

Fakt nr 43: Antyoksydacyjny potencjał hydrolizatu kolagenu rybiego

27 BIOACTIVE COMPOUNDS FROM MARINE PROCESSING BYPRODUCTS – A REVIEW

KIM, Se-Kwon; MENDIS, Eresha. Bioactive compounds from marine processing byproducts–a review. Food research international, 2006, 39.4: 383-393.

28 IDENTIFICATION OF FOOD-DERIVED COLLAGEN PEPTIDES IN HUMAN BLOOD AFTER ORAL INGESTION OF GELATIN HYDROLYSATES

IWAI, Koji, et al. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. Journal of agricultural and food chemistry, 2005, 53.16: 6531-6536.

Fakt nr 7: Kolagen hydrolizowany w formie suplementu wchłania się lepiej niż kolagen w jedzeniu

Fakt nr 53: Hydroksyprolina jako biomarker spożycia kolagenu

29 EFFECTS OF COLLAGEN AND COLLAGEN HYDROLYSATE FROM JELLYFISH (RHOPILEMA ESCULENTUM) ON MICE SKIN PHOTOAGING INDUCED BY UV IRRADIATION

Zhuang Y, Hou H, Zhao X, Zhang Z, Li B. Effects of collagen and collagen hydrolysate from jellyfish (Rhopilema esculentum) on mice skin photoaging induced by UV irradiation. J Food Sci. 2009 Aug;74(6):H183-8. doi: 10.1111/j.1750-3841.2009.01236.x. PMID: 19723203.

30 SKIN MINERALS: KEY ROLES OF INORGANIC ELEMENTS IN SKIN PHYSIOLOGICAL FUNCTIONS

Haftek M, Abdayem R, Guyonnet-Debersac P. Skin Minerals: Key Roles of Inorganic Elements in Skin Physiological Functions. Int J Mol Sci. 2022 Jun 3;23(11):6267. doi: 10.3390/ijms23116267. PMID: 35682946; PMCID: PMC9181837.

Fakt nr 12: Miedź i mangan odgrywają kluczową rolę w syntezie kolagenu w skórze 

Fakt nr 54: Pierwiastki mineralne są kluczowe dla zdrowia skóry i dla tkanki łącznej

31 ORAL ADMINISTRATION OF SKIN GELATIN ISOLATED FROM CHUM SALMON (ONCORHYNCHUS KETA) ENHANCES WOUND HEALING IN DIABETIC RATS

Zhang Z, Zhao M, Wang J, Ding Y, Dai X, Li Y. Oral administration of skin gelatin isolated from Chum salmon (Oncorhynchus keta) enhances wound healing in diabetic rats. Mar Drugs. 2011;9(5):696-711. doi: 10.3390/md9050696. Epub 2011 Apr 26. PMID: 21673883; PMCID: PMC3111176.

32 24-WEEK STUDY ON THE USE OF COLLAGEN HYDROLYSATE AS A DIETARY SUPPLEMENT IN ATHLETES WITH ACTIVITY-RELATED JOINT PAIN

Clark KL, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza F, Millard RL, Deitch JR, Sherbondy PS, Albert A. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. 2008 May;24(5):1485-96. doi: 10.1185/030079908×291967. Epub 2008 Apr 15. PMID: 18416885.

33 INGESTION OF BIOACTIVE COLLAGEN HYDROLYSATES ENHANCE FACIAL SKIN MOISTURE AND ELASTICITY AND REDUCE FACIAL AGEING SIGNS IN A RANDOMISED DOUBLE-BLIND PLACEBO-CONTROLLED CLINICAL STUDY

Inoue N, Sugihara F, Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. J Sci Food Agric. 2016 Sep;96(12):4077-81. doi: 10.1002/jsfa.7606. Epub 2016 Feb 10. PMID: 26840887.

34 EFFECT OF PROLYL-HYDROXYPROLINE (PRO-HYP), A FOOD-DERIVED COLLAGEN PEPTIDE IN HUMAN BLOOD, ON GROWTH OF FIBROBLASTS FROM MOUSE SKIN

Shigemura Y, Iwai K, Morimatsu F, Iwamoto T, Mori T, Oda C, Taira T, Park EY, Nakamura Y, Sato K. Effect of Prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. J Agric Food Chem. 2009 Jan 28;57(2):444-9. doi: 10.1021/jf802785h. PMID: 19128041.

35 ORAL ADMINISTRATION OF 14C LABELED GELATIN HYDROLYSATE LEADS TO AN ACCUMULATION OF RADIOACTIVITY IN CARTILAGE OF MICE (C57/BL)

OESSER, Steffen, et al. Oral Administration of 14C Labeled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL). The Journal of Nutrition, 1999, 129.10: 1891-1895.

Fakt nr 7: Kolagen hydrolizowany w formie suplementu wchłania się lepiej niż kolagen w jedzeniu

36 COLLAGEN HYDROLYSATE INCREASES THE MECHANICAL PROPERTIES AND TYPE II COLLAGEN SYNTHESIS OF TISSUE ENGINEERED ARTICULAR CARTILAGE

NG, K. W., et al. Collagen hydrolysate increases the mechanical properties and type II collagen synthesis of tissue engineered articular cartilage. In: 51st Annual Meeting of the Orthopedic Research Society. 2005.

37 HYDROXYPROLINE-CONTAINING DIPEPTIDES AND TRIPEPTIDES QUANTIFIED AT HIGH CONCENTRATION IN HUMAN BLOOD AFTER ORAL ADMINISTRATION OF GELATIN HYDROLYSATE

Ichikawa S, Morifuji M, Ohara H, Matsumoto H, Takeuchi Y, Sato K. Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate. Int J Food Sci Nutr. 2010 Feb;61(1):52-60. doi: 10.3109/09637480903257711. PMID: 19961355.

38 ABSORPTION AND URINARY EXCRETION OF PEPTIDES AFTER COLLAGEN TRIPEPTIDE INGESTION IN HUMANS

Yamamoto S, Deguchi K, Onuma M, Numata N, Sakai Y. Absorption and Urinary Excretion of Peptides after Collagen Tripeptide Ingestion in Humans. Biol Pharm Bull. 2016;39(3):428-34. doi: 10.1248/bpb.b15-00624. PMID: 26934933.

39 EFFECT OF DIFFERENT CONCENTRATIONS OF COLLAGEN, CERAMIDES, N-ACETYL GLUCOSAMINE, OR THEIR MIXTURE ON ENHANCING THE PROLIFERATION OF KERATINOCYTES, FIBROBLASTS AND THE SECRETION OF COLLAGEN AND/OR THE EXPRESSION OF mRNA OF TYPE I COLLAGEN

CHEN, R.-H., et al. Effect of different concentrations of collagen, ceramides, N-acetyl glucosamine, or their mixture on enhancing the proliferation of keratinocytes, fibroblasts and the secretion of colagen and/or the expression of mRNA of type I collagen. Journal of Food and Drug Analysis, 2008, 16.1: 11.

Fakt nr 6: Można aktywować komórki produkujące kolagen, elastynę i kwas hialuronowy w skórze

Fakt nr 10: Hydrolizowane peptydy kolagenu wpływają na wygląd skóry dzięki 4. głównym mechanizmom

40 COLLAGEN-DERIVED DIPEPTIDE, PROLINE-HYDROXYPROLINE, STIMULATES CELL PROLIFERATION AND HYALURONIC ACID SYNTHESIS IN CULTURED HUMAN DERMAL FIBROBLASTS

Ohara H, Ichikawa S, Matsumoto H, Akiyama M, Fujimoto N, Kobayashi T, Tajima S. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. J Dermatol. 2010 Apr;37(4):330-8. doi: 10.1111/j.1346-8138.2010.00827.x. PMID: 20507402.

Fakt nr 6: Można aktywować komórki produkujące kolagen, elastynę i kwas hialuronowy w skórze

Fakt nr 27: Di-peptydy kolagenowe stymulują tworzenie kwasu hialuronowego w skórze

41 CHEMOTACTIC ATTRACTION OF HUMAN FIBROBLASTS TO TYPE I, II, AND III COLLAGENS AND COLLAGEN-DERIVED PEPTIDES

Postlethwaite AE, Seyer JM, Kang AH. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proc Natl Acad Sci U S A. 1978 Feb;75(2):871-5. doi: 10.1073/pnas.75.2.871. PMID: 204938; PMCID: PMC411359.       

Fakt nr 10: Hydrolizowane peptydy kolagenu wpływają na wygląd skóry dzięki 4. głównym mechanizmom

42 EFFECTS OF INGESTION OF COLLAGEN PEPTIDE ON COLLAGEN FIBRILS AND GLYCOSAMINOGLYCANS IN THE DERMIS

Matsuda N, Koyama Y, Hosaka Y, Ueda H, Watanabe T, Araya T, Irie S, Takehana K. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J Nutr Sci Vitaminol (Tokyo). 2006 Jun;52(3):211-5. doi: 10.3177/jnsv.52.211. PMID: 16967766.

Fakt nr 10: Hydrolizowane peptydy kolagenu wpływają na wygląd skóry dzięki 4. głównym mechanizmom

43 COLLAGEN PEPTIDE AND VITAMIN C ADDITIVELY ATTENUATE AGE-RELATED SKIN ATROPHY IN SOD1-DEFICIENT MICE

Shibuya S, Ozawa Y, Toda T, Watanabe K, Tometsuka C, Ogura T, Koyama Y, Shimizu T. Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice. Biosci Biotechnol Biochem. 2014;78(7):1212-20. doi: 10.1080/09168451.2014.915728. Epub 2014 May 28. PMID: 25229861.

44 THE PROTECTIVE EFFECTS OF LONG-TERM ORAL ADMINISTRATION OF MARINE COLLAGEN HYDROLYSATE FROM CHUM SALMON ON COLLAGEN MATRIX HOMEOSTASIS IN THE CHRONOLOGICAL AGED SKIN OF SPRAGUE-DAWLEY MALE RATS

Liang J, Pei X, Zhang Z, Wang N, Wang J, Li Y. The protective effects of long-term oral administration of marine collagen hydrolysate from chum salmon on collagen matrix homeostasis in the chronological aged skin of Sprague-Dawley male rats. J Food Sci. 2010 Oct;75(8):H230-8. doi: 10.1111/j.1750-3841.2010.01782.x. Epub 2010 Sep 24. PMID: 21535500.

45 EFFECTS OF INGESTION OF COLLAGEN PEPTIDE ON COLLAGEN FIBRILS AND GLYCOSAMINOGLYCANS IN ACHILLES TENDON

Minaguchi J, Koyama Y, Meguri N, Hosaka Y, Ueda H, Kusubata M, Hirota A, Irie S, Mafune N, Takehana K. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in Achilles tendon. J Nutr Sci Vitaminol (Tokyo). 2005 Jun;51(3):169-74. doi: 10.3177/jnsv.51.169. PMID: 16161767.

46 ORAL ADMINISTRATION OF MARINE COLLAGEN PEPTIDES FROM CHUM SALMON SKIN ENHANCES CUTANEOUS WOUND HEALING AND ANGIOGENESIS IN RATS

Zhang Z, Wang J, Ding Y, Dai X, Li Y. Oral administration of marine collagen peptides from Chum Salmon skin enhances cutaneous wound healing and angiogenesis in rats. J Sci Food Agric. 2011 Sep;91(12):2173-9. doi: 10.1002/jsfa.4435. Epub 2011 May 10. PMID: 21560132.

47 IMPROVEMENT IN THE MOISTURE CONTENT OF THE STRATUM CORNEUM FOLLOWING 4 WEEKS OF COLLAGEN HYDROLYSATE INGESTION

OHARA, H., et al. Improvement in the moisture content of the stratum corneum following 4 weeks of collagen hydrolysate ingestion. Nippon Shokuhin Kagaku Kogaku Kaishi= Journal of the Japanese Society for Food Science and Technology, 2009, 56.3: 137-145.

48 EFFECTS OF COLLAGEN PEPTIDE INGESTION ON UV-B-INDUCED SKIN DAMAGE

Tanaka M, Koyama Y, Nomura Y. Effects of collagen peptide ingestion on UV-B-induced skin damage. Biosci Biotechnol Biochem. 2009 Apr 23;73(4):930-2. doi: 10.1271/bbb.80649. Epub 2009 Apr 7. PMID: 19352014.

49 ORAL SUPPLEMENTATION OF SPECIFIC COLLAGEN PEPTIDES HAS BENEFICIAL EFFECTS ON HUMAN SKIN PHYSIOLOGY: A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55. doi: 10.1159/000351376. Epub 2013 Aug 14. PMID: 23949208

Fakt nr 29: Di- oraz tripeptydy kolagenu najszybciej przedostają się przez jelita do krwi, a następnie do tkanki skórnej

Fakt nr 30: Najważniejsze peptydy i polipetydy kolagenowe i ich wpływ na skórę

Fakt nr 32: Kolagen rybi różni się od kolagenu wołowego i wieprzowego

Fakt nr 34: Efekty suplementacji kolagenem na skórze twarzy można zobaczyć po 4-8 tygodniach

50 DIETARY SUPPLEMENTATION WITH SPECIFIC COLLAGEN PEPTIDES HAS A BODY MASS INDEX-DEPENDENT BENEFICIAL EFFECT ON CELLULITE MORPHOLOGY

Schunck M, Zague V, Oesser S, Proksch E. Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. J Med Food. 2015 Dec;18(12):1340-8. doi: 10.1089/jmf.2015.0022. Epub 2015 Nov 12. PMID: 26561784; PMCID: PMC4685482.

Fakt nr 19: Kolagen Verisol® może pomóc w redukcji cellulitu

Fakt nr 32: Kolagen rybi różni się od kolagenu wołowego i wieprzowego

Fakt nr 34: Efekty suplementacji kolagenem na skórze twarzy można zobaczyć po 4-8 tygodniach

Fakt nr 35: Efekty suplementacji kolagenem na paznokciach, udach i pośladkach są widoczne po ok. 6 miesiącach

51 ORAL SUPPLEMENTATION WITH SPECIFIC BIOACTIVE COLLAGEN PEPTIDES IMPROVES NAIL GROWTH AND REDUCES SYMPTOMS OF BRITTLE NAILS

Hexsel D, Zague V, Schunck M, Siega C, Camozzato FO, Oesser S. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. J Cosmet Dermatol. 2017 Dec;16(4):520-526. doi: 10.1111/jocd.12393. Epub 2017 Aug 8. PMID: 28786550.

Fakt nr 21: Peptydy VERISOL® promują zdrowy wzrost paznokci

Fakt nr 32: Kolagen rybi różni się od kolagenu wołowego i wieprzowego

Fakt nr 35: Efekty suplementacji kolagenem na paznokciach, udach i pośladkach są widoczne po ok. 6 miesiącach

52 THE ORAL INTAKE OF SPECIFIC BIOACTIVE COLLAGEN PEPTIDES HAS A POSITIVE EFFECT ON HAIR THICKNESS

OESSER, Steffen. The oral intake of specific Bioactive Collagen Peptides has a positive effect on hair thickness. International Journal on Nutraceuticals, Functional Foods and Novel Foods, 2020.

Fakt nr 20: Kolagen Verisol® może wpłynąć na wzrost grubości włosów

Fakt nr 32: Kolagen rybi różni się od kolagenu wołowego i wieprzowego

Fakt nr 55: Efekty suplementacji kolagenem na włosach są widoczne po ok. 4 miesiącach

53 POSITIVE EFFECT OF BIOACTIVE COLLAGEN PEPTIDES OF FISH ORIGIN ON SKIN HEALTH

OESSER, Steffen; SCHUNK, M.; PROKSCH, E. Positive effect of fish-derived Bioactive Collagen Peptides on skin health. International Journal on Nutraceuticals, Functional Foods and Novel Foods, 2020.

Fakt nr 29: Di- oraz tripeptydy kolagenu najszybciej przedostają się przez jelita do krwi, a następnie do tkanki skórnej

Fakt nr 30: Najważniejsze peptydy i polipetydy kolagenowe i ich wpływ na skórę

Fakt nr 32: Kolagen rybi różni się od kolagenu wołowego i wieprzowego

Fakt nr 34: Efekty suplementacji kolagenem na skórze twarzy można zobaczyć po 4-8 tygodniach

54 FISH COLLAGEN PEPTIDE (NATICOL®) PROTECTS THE SKIN FROM DRYNESS, WRINKLE FORMATION, AND MELANOGENESIS BOTH IN VITRO AND IN VIVO

Lee M, Kim D, Park SH, Jung J, Cho W, Yu AR, Lee J. Fish Collagen Peptide (Naticol®) Protects the Skin from Dryness, Wrinkle Formation, and Melanogenesis Both In Vitro and In Vivo. Prev Nutr Food Sci. 2022 Dec 31;27(4):423-435. doi: 10.3746/pnf.2022.27.4.423. PMID: 36721753; PMCID: PMC9843708.

Fakt nr 15: Peptydy kolagenowe chronią skórę przed suchością, powstawaniem zmarszczek i melanogenezą zarówno in vitro jak in vivo 

Fakt nr 29: Di- oraz tripeptydy kolagenu najszybciej przedostają się przez jelita do krwi, a następnie do tkanki skórnej

Fakt nr 30: Najważniejsze peptydy i polipetydy kolagenowe i ich wpływ na skórę

55 EFFECT SIZE STATISTICS TO INFORM AN EXPLORATORY ANALYSIS OF A DOUBLE-BLINDED, RANDOMISED, PLACEBO CONTROLLED PILOT CLINICAL STUDY TO EVALUATE THE EFFICACY OF NATICOL ®, SPECIFIC FISH COLLAGEN PEPTIDES TO ALLEVIATE SYMPTOMS OF OSTEOARTHRITIS IN THE KNEE

LACEY, SeÃ, et al. Effect Size Statistics to Inform an Exploratory Analysis of a Double-Blinded, Randomised, Placebo Controlled Pilot Clinical Study to Evaluate the Efficacy of Naticol®, Specific Fish Collagen Peptides to Alleviate Symptoms of Osteoarthritis in the Knee. Juniper Online Journal of Case Studies, 2019, 10.2: 30-37.

Fakt nr 18: Dlaczego peptydy kolagenowe mają potencjał poprawy funkcji ciała w ChzS – mechanizm działania, wnioski z badań

Fakt nr 64: Bezpieczeństwo i tolerancja doustnego podawania konkretnych peptydów kolagenu rybiego u osób z artrozą (ChZS) kolana – opis badania

56 SPECIFIC NATURAL BIOACTIVE TYPE I COLLAGEN PEPTIDES ORAL INTAKE REVERSE SKIN AGING SIGNS IN MATURE WOMEN

DUTEIL, L., et al. SPECIFIC NATURAL BIOACTIVE TYPE 1 COLLAGEN PEPTIDES ORAL INTAKE REVERSE SKIN AGING SIGNS IN MATURE WOMEN.

Fakt nr 16: Badanie kliniczne wskazało na poprawę jędrności skóry i zmniejszenie zmarszczek po 4 i 8 tygodniach przyjmowania peptydów kolagenu

57 THE EFFECT OF ORAL COLLAGEN PEPTIDE SUPPLEMENTATION ON SKIN MOISTURE AND THE DERMAL COLLAGEN NETWORK: EVIDENCE FROM AN EX VIVO MODEL AND RANDOMIZED, PLACEBO-CONTROLLED CLINICAL TRIALS

Asserin J, Lati E, Shioya T, Prawitt J. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015 Dec;14(4):291-301.

Fakt nr 2: Proces starzenia się skóry jest powiązany z mniejszą gęstością kolagenu

Fakt nr 9: Di- i tripeptydy kolagenu są odporne na dalsze trawienie

Fakt nr 29: Di- oraz tripeptydy kolagenu najszybciej przedostają się przez jelita do krwi, a następnie do tkanki skórnej

Fakt nr 30: Najważniejsze peptydy i polipetydy kolagenowe i ich wpływ na skórę

58 ORAL HYDROLYZED TYPE 1 COLLAGEN INDUCES CHONDROREGENERATION AND INHIBITS SYNOVIAL INFLAMMATION IN MURINE POSTTRAUMATIC OSTEOARTHRITIS

DAR, Q.-A., et al. Oral hydrolyzed type 1 collagen induces chondroregeneration and inhibits synovial inflammation in murine posttraumatic osteoarthritis. Osteoarthritis and Cartilage, 2016, 24: S532-S533.

59 RESPONSE TO HYDROLYSED COLLAGEN PROTEIN SUPPLEMENTATION IN A COHORT OF PREGNANT AND POST-PARTUM WOMEN

BAGINSKI, L., et al. Response to Hydrolyzed Collagen Protein Supplementation in a Cohort of Pregnant and Postpartum Women. J Preg Child Health, 2016, 3.275: 2.

60 THE EFFECTS OF EXCESS AMINO ACIDS ON MAINTENANCE OF PREGNANCY AND FETAL GROWTH IN RATS

Matsueda S, Niiyama Y. The effects of excess amino acids on maintenance of pregnancy and fetal growth in rats. J Nutr Sci Vitaminol (Tokyo). 1982 Oct;28(5):557-73. doi: 10.3177/jnsv.28.557. PMID: 7161652.

61 COMPARISON OF QUANTITY AND STRUCTURES OF HYDROXYPROLINE-CONTAINING PEPTIDES IN HUMAN BLOOD AFTER ORAL INGESTION OF GELATIN HYDROLYSATES FROM DIFFERENT SOURCES

Ohara H, Matsumoto H, Ito K, Iwai K, Sato K. Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources. J Agric Food Chem. 2007 Feb 21;55(4):1532-5. doi: 10.1021/jf062834s. Epub 2007 Jan 25. PMID: 17253720.

62 ABSORPTION AND EFFECTIVENESS OF ORALLY ADMINISTERED LOW MOLECULAR WEIGHT COLLAGEN HYDROLYSATE IN RATS

Watanabe-Kamiyama M, Shimizu M, Kamiyama S, Taguchi Y, Sone H, Morimatsu F, Shirakawa H, Furukawa Y, Komai M. Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats. J Agric Food Chem. 2010 Jan 27;58(2):835-41. doi: 10.1021/jf9031487. PMID: 19957932.

Fakt nr 7: Kolagen hydrolizowany w formie suplementu wchłania się lepiej niż kolagen w jedzeniu

63 ORAL INTAKE OF LOW-MOLECULAR-WEIGHT COLLAGEN PEPTIDE IMPROVES HYDRATION, ELASTICITY, AND WRINKLING IN HUMAN SKIN: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2018 Jun 26;10(7):826. doi: 10.3390/nu10070826. PMID: 29949889; PMCID: PMC6073484.

64 A NOVEL MICRONUTRIENT SUPPLEMENT IN SKIN AGING: A RANDOMIZED PLACEBO-CONTROLLED DOUBLE-BLIND STUDY

Béguin A. A novel micronutrient supplement in skin aging: a randomized placebo-controlled double-blind study. J Cosmet Dermatol. 2005 Dec;4(4):277-84. doi: 10.1111/j.1473-2165.2005.00206.x. PMID: 17168877.

65 EFFECTS OF COLLAGEN TRIPEPTIDE SUPPLEMENT ON SKIN PROPERTIES: A PROSPECTIVE, RANDOMIZED, CONTROLLED STUDY

Choi SY, Ko EJ, Lee YH, Kim BG, Shin HJ, Seo DB, Lee SJ, Kim BJ, Kim MN. Effects of collagen tripeptide supplement on skin properties: a prospective, randomized, controlled study. J Cosmet Laser Ther. 2014 Jun;16(3):132-7.

Fakt nr 29: Di- oraz tripeptydy kolagenu najszybciej przedostają się przez jelita do krwi, a następnie do tkanki skórnej

66 AMINO ACID COMPOSITION AND ANTIOXIDANT ACTIVITIES OF HYDROLYSATES AND PEPTIDE FRACTIONS FROM PORCINE COLLAGEN

Ao J, Li B. Amino acid composition and antioxidant activities of hydrolysates and peptide fractions from porcine collagen. Food Sci Technol Int. 2012 Oct;18(5):425-34. doi: 10.1177/1082013211428219. Epub 2012 Oct 11. PMID: 23064526.

Fakt nr 25: Typ suplementowanego kolagenu ma mały wpływ na rezultaty suplementacji

67 COLLAGEN AND GELATIN

Liu D, Nikoo M, Boran G, Zhou P, Regenstein JM. Collagen and gelatin. Annu Rev Food Sci Technol. 2015;6:527-57. doi: 10.1146/annurev-food-031414-111800. Epub 2015 Mar 23. PMID: 25884286.

68 MARINE COLLAGEN PEPTIDES FROM THE SKIN OF NILE TILAPIA (OREOCHROMIS NILOTICUS): CHARACTERIZATION AND WOUND HEALING EVALUATION

Hu Z, Yang P, Zhou C, Li S, Hong P. Marine Collagen Peptides from the Skin of Nile Tilapia (Oreochromis niloticus): Characterization and Wound Healing Evaluation. Mar Drugs. 2017 Mar 30;15(4):102. doi: 10.3390/md15040102. PMID: 28358307; PMCID: PMC5408248.

69 CLINICAL EFFECTS OF INGESTING COLLAGEN HYDROLYSATE ON FACIAL SKIN PROPERTIES

SUGIHARA, Fumihito; INOUE, Naoki; WANG, Xuemin. Clinical effects of ingesting collagen hydrolysate on facial skin properties. Jpn Pharmacol Ther, 2015, 43: 67-70.

Fakt nr 67: Suplementacja kolagenu o masie cząsteczkowej 1000 Da i 2000 Da – porównywalna skuteczność

70 EFFECT OF HIGH ADVANCED-COLLAGEN TRIPEPTIDE ON WOUND HEALING AND SKIN RECOVERY AFTER FRACTIONAL PHOTOTHERMOLYSIS TREATM

Choi SY, Kim WG, Ko EJ, Lee YH, Kim BG, Shin HJ, Choi YS, Ahn JY, Kim BJ, Lee HJ. Effect of high advanced-collagen tripeptide on wound healing and skin recovery after fractional photothermolysis treatment. Clin Exp Dermatol. 2014 Dec;39(8):874-80. doi: 10.1111/ced.12405. Epub 2014 Oct 4. PMID: 25283252.   

71 CLINICAL EFFECTS OF COLLAGEN HYDROLYSATES INGESTION ON UV-INDUCED PIGMENTED SPOTS OF HUMAN SKIN: A PRELIMINARY STUDY

SUGIHARA, Fumihito; INOUE, Naoki. Clinical effects of collagen hydrolysates ingestion on UV-induced pigmented spots of human skin: A preliminary study. Health Sci, 2012, 28.2: 15.3-6.               

72 CLINICAL EFFECTS OF INGESTING COLLAGEN HYDROLYSATE ONFACIAL SKIN PROPERTIES

SUGIHARA, Fumihito; INOUE, Naoki; WANG, Xuemin. Clinical effects of ingesting collagen hydrolysate on facial skin properties. Jpn Pharmacol Ther, 2015, 43: 67-70.

73 QUANTIFICATION OF HYDROXYPROLYL-GLYCINE (HYP-GLY) IN HUMAN BLOOD AFTER INGESTION OF COLLAGEN HYDROLYSATE

Sugihara F, Inoue N, Kuwamori M, Taniguchi M. Quantification of hydroxyprolyl-glycine (Hyp-Gly) in human blood after ingestion of collagen hydrolysate. J Biosci Bioeng. 2012 Feb;113(2):202-3. doi: 10.1016/j.jbiosc.2011.09.024. Epub 2011 Oct 29. PMID: 22040651.

74 COLLAGEN HYDROLYSATE INTAKE INCREASES SKIN COLLAGEN EXPRESSION AND SUPPRESSES MATRIX METALLOPROTEINASE 2 ACTIVITY

Zague V, de Freitas V, da Costa Rosa M, de Castro GÁ, Jaeger RG, Machado-Santelli GM. Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity. J Med Food. 2011 Jun;14(6):618-24. doi: 10.1089/jmf.2010.0085. Epub 2011 Apr 11. PMID: 21480801.

75 EINFLUSS ORALER EINNAHME VON KOLLAGEN-PEPTIDEN AUF RELEVANTE PARAMETER DER HAUTALTERUNG: HAUTFEUCHTIGKEIT, HAUTELASTIZITÄT UND HAUTRAUIGKEIT

SCHLIPPE, G.; BOLKE, L.; VOSS, W. Einfluss oraler Einnahme von Kollagen-Peptiden auf relevante Parameter der Hautalterung: Hautfeuchtigkeit, Hautelastizität und Hautrauigkeit. Aktuelle Dermatologie, 2015, 529-534.

76 COLLAGEN PRODUCT CONTAINING COLLAGEN OF MARINE ORIGIN WITH A LOW ODOR AND PREFERABLY WITH IMPROVED MECHANICAL PROPERTIES, AND ITS USE IN THE FORM OF COSMETIC OR PHARMACEUTICAL COMPOSITIONS OR PRODUCTS

ALLARD, Roland; MALAK, Nabil Abdul; HUC, Alain. Collagen product containing collagen of marine origin with a low odor and preferably with improved mechanical properties, and its use in the form of cosmetic or pharmaceutical compositions or products. U.S. Patent No 6,660,280, 2003.

77 IN VITRO ANTIOXIDANT ACTIVITY OF A PEPTIDE ISOLATED FROM NILE TILAPIA (OREOCHROMIS NILOTICUS) SCALE GELATIN IN FREE RADICAL-MEDIATED OXIDATIVE SYSTEMS

NGO, Dai-Hung, et al. In vitro antioxidant activity of a peptide isolated from Nile tilapia (Oreochromis niloticus) scale gelatin in free radical-mediated oxidative systems. Journal of Functional Foods, 2010, 2.2: 107-117.

Fakt nr 5: Wolne rodniki są przyczyną starzenia się skóry. Indukują niszczenie kolagenu w skórze

Fakt nr 43: Antyoksydacyjny potencjał hydrolizatu kolagenu rybiego

78 ANTIMICROBIAL PEPTIDES AND THE SKIN

Bardan A, Nizet V, Gallo RL. Antimicrobial peptides and the skin. Expert Opin Biol Ther. 2004 Apr;4(4):543-9. doi: 10.1517/14712598.4.4.543. PMID: 15102603.

79 EFFECTS OF COLLAGEN AND COLLAGEN HYDROLYSATE FROM JELLYFISH UMBRELLA ON HISTOLOGICAL AND IMMUNITY CHANGES OF MICE PHOTOAGING

Fan J, Zhuang Y, Li B. Effects of collagen and collagen hydrolysate from jellyfish umbrella on histological and immunity changes of mice photoaging. Nutrients. 2013 Jan 17;5(1):223-33. doi: 10.3390/nu5010223. PMID: 23344251; PMCID: PMC3571645.

80 MOISTURE ABSORPTION AND RETENTION PROPERTIES, AND ACTIVITY IN ALLEVIATING SKIN PHOTODAMAGE OF COLLAGEN POLYPEPTIDE FROM MARINE FISH SKIN

Hou H, Li B, Zhang Z, Xue C, Yu G, Wang J, Bao Y, Bu L, Sun J, Peng Z, Su S. Moisture absorption and retention properties, and activity in alleviating skin photodamage of collagen polypeptide from marine fish skin. Food Chem. 2012 Dec 1;135(3):1432-9. doi: 10.1016/j.foodchem.2012.06.009. Epub 2012 Jun 15. PMID: 22953877.

81 POSTMENOPAUSAL OSTEOPOROSIS. TREATMENT WITH CALCITONIN AND A DIET RICH IN COLLAGEN PROTEINS

Adam M, Spacek P, Hulejová H, Galiánová A, Blahos J. Postmenopauzální osteoporóza. Lécba kalcitoninem pri dietĕ bohaté na kolagenní bílkoviny [Postmenopausal osteoporosis. Treatment with calcitonin and a diet rich in collagen proteins]. Cas Lek Cesk. 1996 Jan 31;135(3):74-8. Czech. PMID: 8625373.

82 IMPROVEMENT OF ACTIVITY-RELATED KNEE JOINT DISCOMFORT FOLLOWING SUPPLEMENTATION OF SPECIFIC COLLAGEN PEPTIDES

Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Appl Physiol Nutr Metab. 2017 Jun;42(6):588-595. doi: 10.1139/apnm-2016-0390. Epub 2017 Jan 24. Erratum in: Appl Physiol Nutr Metab. 2017 Nov;42(11):1237. PMID: 28177710.

83 IMPROVEMENT OF FUNCTIONAL ANKLE PROPERTIES FOLLOWING SUPPLEMENTATION WITH SPECIFIC COLLAGEN PEPTIDES IN ATHLETES WITH CHRONIC ANKLE INSTABILITY

Dressler P, Gehring D, Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of Functional Ankle Properties Following Supplementation with Specific Collagen Peptides in Athletes with Chronic Ankle Instability. J Sports Sci Med. 2018 May 14;17(2):298-304. PMID: 29769831; PMCID: PMC5950747.     

84 ORAL SUPPLEMENTATION OF SPECIFIC COLLAGEN PEPTIDES COMBINED WITH CALF-STRENGTHENING EXERCISES ENHANCES FUNCTION AND REDUCES PAIN IN ACHILLES TENDINOPATHY PATIENTS

Praet SFE, Purdam CR, Welvaert M, Vlahovich N, Lovell G, Burke LM, Gaida JE, Manzanero S, Hughes D, Waddington G. Oral Supplementation of Specific Collagen Peptides Combined with Calf-Strengthening Exercises Enhances Function and Reduces Pain in Achilles Tendinopathy Patients. Nutrients. 2019 Jan 2;11(1):76. doi: 10.3390/nu11010076. PMID: 30609761; PMCID: PMC6356409.

85 STIMULATION OF TYPE II COLLAGEN BIOSYNTHESIS AND SECRETION IN BOVINE CHONDROCYTES CULTURED WITH DEGRADED COLLAGEN

Oesser S, Seifert J. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res. 2003 Mar;311(3):393-9. doi: 10.1007/s00441-003-0702-8. Epub 2003 Feb 25. PMID: 12658447.

86 PROLONGED COLLAGEN PEPTIDE SUPPLEMENTATION AND RESISTANCE EXERCISE TRAINING AFFECTS BODY COMPOSITION IN RECREATIONALLY ACTIVE MEN

Kirmse M, Oertzen-Hagemann V, de Marées M, Bloch W, Platen P. Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men. Nutrients. 2019 May 23;11(5):1154. doi: 10.3390/nu11051154. PMID: 31126103; PMCID: PMC6566878.

87 EFFECTS OF 12 WEEKS OF HYPERTROPHY RESISTANCE EXERCISE TRAINING COMBINED WITH COLLAGEN PEPTIDE SUPPLEMENTATION ON THE SKELETAL MUSCLE PROTEOME IN RECREATIONALLY ACTIVE MEN

Oertzen-Hagemann V, Kirmse M, Eggers B, Pfeiffer K, Marcus K, de Marées M, Platen P. Effects of 12 Weeks of Hypertrophy Resistance Exercise Training Combined with Collagen Peptide Supplementation on the Skeletal Muscle Proteome in Recreationally Active Men. Nutrients. 2019 May 14;11(5):1072. doi: 10.3390/nu11051072. PMID: 31091754; PMCID: PMC6566884.

88 SPECIFIC COLLAGEN PEPTIDES IN COMBINATION WITH RESISTANCE TRAINING IMPROVE BODY COMPOSITION AND REGIONAL MUSCLE STRENGTH IN PREMENOPAUSAL WOMEN: A RANDOMIZED CONTROLLED TRIAL

Jendricke P, Centner C, Zdzieblik D, Gollhofer A, König D. Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial. Nutrients. 2019 Apr 20;11(4):892. doi: 10.3390/nu11040892. PMID: 31010031; PMCID: PMC6521629.

89 THE EFFECTS OF COLLAGEN PEPTIDES ON MUSCLE DAMAGE, INFLAMMATION AND BONE TURNOVER FOLLOWING EXERCISE: A RANDOMIZED, CONTROLLED TRIAL

Clifford T, Ventress M, Allerton DM, Stansfield S, Tang JCY, Fraser WD, Vanhoecke B, Prawitt J, Stevenson E. The effects of collagen peptides on muscle damage, inflammation and bone turnover following exercise: a randomized, controlled trial. Amino Acids. 2019 Apr;51(4):691-704. doi: 10.1007/s00726-019-02706-5. Epub 2019 Feb 19. PMID: 30783776.

90 VITAMIN C–ENRICHED GELATIN SUPPLEMENTATION BEFORE INTERMITTENT ACTIVITY AUGMENTS COLLAGEN SYNTHESIS

Shaw G, Lee-Barthel A, Ross ML, Wang B, Baar K. Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis. Am J Clin Nutr. 2017 Jan;105(1):136-143. doi: 10.3945/ajcn.116.138594. Epub 2016 Nov 16. PMID: 27852613; PMCID: PMC5183725.

91 FFECTS OF DIFFERENT VITAMIN C-ENRICHED COLLAGEN DERIVATIVES ON COLLAGEN SYNTHESIS

Lis DM, Baar K. Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis. Int J Sport Nutr Exerc Metab. 2019 Sep 1;29(5):526-531. doi: 10.1123/ijsnem.2018-0385. PMID: 30859848.

92 SPECIFIC COLLAGEN PEPTIDES BENEFIT THE BIOSYNTHESIS OF MATRIX MOLECULES OF TENDONS AND LIGAMENTS

Schunck and Oesser: Specific collagen peptides benefit the biosynthesis of matrix molecules of tendons and ligaments. Journal of the International Society of Sports Nutrition 2013 10(Suppl 1):P23.

93 COLLAGEN HYDROLYSATE INHIBITS ZYMOSAN-INDUCED INFLAMMATION

Hartog A, Cozijnsen M, de Vrij G, Garssen J. Collagen hydrolysate inhibits zymosan-induced inflammation. Exp Biol Med (Maywood). 2013 Jul;238(7):798-802. doi: 10.1177/1535370213480740. Epub 2013 Jun 20. PMID: 23788175.

Fakt nr 42: Hydrolizat kolagenu może działać przeciwzapalnie – opis badania

94 GLYCINE IMPROVES THE REMODELING PROCESS OF TENOCYTES IN VITRO

Vieira CP, Viola M, Carneiro GD, D’Angelo ML, Vicente CP, Passi A, Pimentel ER. Glycine improves the remodeling process of tenocytes in vitro. Cell Biol Int. 2018 Jul;42(7):804-814. doi: 10.1002/cbin.10937. Epub 2018 Feb 8. PMID: 29345399.

Fakt nr 36: Wpływ glicyny z hydrolizatu kolagenu na ścięgna

95 AMELIORATION OF ESTROGEN DEFICIENCY-INDUCED OBESITY BY COLLAGEN HYDROLYSATE

Chiang TI, Chang IC, Lee HH, Hsieh KH, Chiu YW, Lai TJ, Liu JY, Hsu LS, Kao SH. Amelioration of estrogen deficiency-induced obesity by collagen hydrolysate. Int J Med Sci. 2016 Oct 19;13(11):853-857. doi: 10.7150/ijms.16706. PMID: 27877077; PMCID: PMC5118756.

96 PURIFICATION AND CHARACTERIZATION OF ANTIOXIDATIVE PEPTIDES FROM BOVINE SKIN

KIM, Se Kwon, et al. Purification and characterization of antioxidative peptides from bovine skin. BMB Reports, 2001, 34.3: 219-224.

97 IDENTIFICATION OF A NOVEL FOOD-DERIVED COLLAGEN PEPTIDE, HYDROXYPROLYL-GLYCINE, IN HUMAN PERIPHERAL BLOOD BY PRE-COLUMN DERIVATISATION WITH PHENYL ISOTHIOCYANATE

Shigemura Y, Akaba S, Kawashima E, Park EY, Nakamura Y, Sato K. Identification of a novel food-derived collagen peptide, hydroxyprolyl-glycine, in human peripheral blood by pre-column derivatisation with phenyl isothiocyanate. Food Chem. 2011 Dec 1;129(3):1019-24

98 STRUCTURAL AND PHYSICAL PROPERTIES OF GELATIN EXTRACTED FROM DIFFERENT MARINE SPECIES: A COMPARATIVE STUDY

GÓMEZ-GUILLÉN, Mª C., et al. Structural and physical properties of gelatin extracted from different marine species: a comparative study. Food Hydrocolloids, 2002, 16.1: 25-34.

99 ENZYMATIC HYDROLYSIS OF PROTEINS FROM YELLOWFIN TUNA (THUNNUS ALBACARES) WASTES USING ALCALASE

GUERARD, F., et al. Enzymatic hydrolysis of proteins from yellowfin tuna (Thunnus albacares) wastes using Alcalase. Journal of Molecular Catalysis B: Enzymatic, 2001, 11.4-6: 1051-1059.

100 CLINICAL DEVELOPMENT OF CATIONIC ANTIMICROBIAL PEPTIDES: FROM NATURAL TO NOVEL ANTIBIOTICS

Hancock RE, Patrzykat A. Clinical development of cationic antimicrobial peptides: from natural to novel antibiotics. Curr Drug Targets Infect Disord. 2002 Mar;2(1):79-83. doi: 10.2174/1568005024605855. PMID: 12462155.

101 BIOACTIVE COMPOUNDS FROM MARINE PROCESSING BYPRODUCTS – A REVIEW

KIM, Se-Kwon; MENDIS, Eresha. Bioactive compounds from marine processing byproducts–a review. Food research international, 2006, 39.4: 383-393.

102 ABSORPTION OF HYDROXYPROLINE-CONTAINING PEPTIDES IN VASCULARLY PERFUSED RAT SMALL INTESTINE IN SITU

Liu C, Sugita K, Nihei K, Yoneyama K, Tanaka H. Absorption of hydroxyproline-containing peptides in vascularly perfused rat small intestine in situ. Biosci Biotechnol Biochem. 2009 Aug;73(8):1741-7.

Fakt nr 9: Di- i tripeptydy kolagenu są odporne na dalsze trawienie

Fakt nr 33: Kolagen wieprzowy wykazuje w badaniach porównawczych lepsze parametry poprawy nawilżenia niż kolagen rybi tej samej marki

103 SYMPTOMATIC AND CHONDROPROTECTIVE TREATMENT WITH COLLAGEN DERIVATIVES IN OSTEOARTHRITIS: A SYSTEMATIC REVIEW

Van Vijven JP, Luijsterburg PA, Verhagen AP, van Osch GJ, Kloppenburg M, Bierma-Zeinstra SM. Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: a systematic review. Osteoarthritis Cartilage. 2012 Aug;20(8):809-21. doi: 10.1016/j.joca.2012.04.008. Epub 2012 Apr 17. PMID: 22521757.

104 ASSESSMENT OF EFFECTIVENESS OF ORAL ADMINISTRATION OF COLLAGEN PEPTIDE ON BONE METABOLISM IN GROWING AND MATURE RATS

Wu J, Fujioka M, Sugimoto K, Mu G, Ishimi Y. Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats. J Bone Miner Metab. 2004;22(6):547-53. PMID: 15490264.

105 PHYSIOLOGICAL FUNCTIONS OF ENZYMATIC HYDROLYSATES OF COLLAGEN OR KERATIN CONTAINED IN LIVESTOCK AND FISH WASTE

OHBA, Riichiro, et al. Physiological functions of enzymatic hydrolysates of collagen or keratin contained in livestock and fish waste. Food Science and Technology Research, 2003, 9.1: 91-93.

106 CLINICAL EFFECTS OF FISH TYPE I COLLAGEN HYDROLYSATE ON SKIN PROPERTIES

MATSUMOTO, H. Clinical effects of fish type I collagen hydrolysate on skin properties. ITE Letters., 2006, 7: 386-390.

107 REGULATION OF EXPRESSION OF THE INTESTINAL OLIGOPEPTIDE TRANSPORTER (PEPT-1) IN HEALTH AND DISEASE

Adibi SA. Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease. Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G779-88. doi: 10.1152/ajpgi.00056.2003. PMID: 14561585.

108 A NUTRITIONAL SUPPLEMENT FORMULATED WITH PEPTIDES, LIPIDS, COLLAGEN AND HYALURONIC ACID OPTIMIZES KEY ASPECTS OF PHYSICAL APPEARANCE IN NAILS, HAIR AND SKIN

YAGODA, M.; GANS, E. A nutritional supplement formulated with peptides, lipids, collagen and hyaluronic acid optimizes key aspects of physical appearance in nails, hair and skin. J. Nutr Food Sci. S, 2014, 5.002.

109 EFFECT OF OVEN DRYING AND FREEZE DRYING ON THE ANTIOXIDANT AND FUNCTIONAL PROPERTIES OF PROTEIN HYDROLYSATES DERIVE FROM FRESHWATER FISH (CIRRHINUS MRIGALA) USING PAPAIN ENZYME

Elavarasan K, Shamasundar BA. Effect of oven drying and freeze drying on the antioxidant and functional properties of protein hydrolysates derived from freshwater fish (Cirrhinus mrigala) using papain enzyme. J Food Sci Technol. 2016 Feb;53(2):1303-11. doi: 10.1007/s13197-015-2084-9. Epub 2015 Nov 5. PMID: 27162411; PMCID: PMC4837731.

Fakt nr 28: Skuteczność hydrolizatu kolagenu jest potwierdzona badaniami klinicznymi, skuteczność liofilizatu kolagenu nie jest potwierdzona

110 COLLAGEN HYDROLYSATE INTAKE INCREASES SKIN COLLAGEN EXPRESSION AND SUPPRESSES MATRIX METALLOPROTEINASE 2 ACTIVITY

ZAGUE, Vivian, et al. Collagen Hydrolysate Intake Increases Skin Collagen Expression and Suppresses Matrix Metalloproteinase 2 Activity. J Med Food, 2011, 14.6: 618-624.

111 DISTRIBUTION OF PROLYLHYDROXYPROLINE AND ITS METABOLITES AFTER ORAL ADMINISTRATION IN RATS

Kawaguchi T, Nanbu PN, Kurokawa M. Distribution of prolylhydroxyproline and its metabolites after oral administration in rats. Biol Pharm Bull. 2012;35(3):422-7. doi: 10.1248/bpb.35.422. PMID: 22382331.

112 EFFICACY OF VITAMIN C SUPPLEMENTATION ON COLLAGEN SYNTHESIS AND OXIDATIVE STRESS AFTER MUSCULOSKELETAL INJURIES: A SYSTEMATIC REVIEW

DePhillipo NN, Aman ZS, Kennedy MI, Begley JP, Moatshe G, LaPrade RF. Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthop J Sports Med. 2018 Oct 25;6(10):2325967118804544. doi: 10.1177/2325967118804544. PMID: 30386805; PMCID: PMC6204628.

113 EFFECTS OF ORAL COLLAGEN FOR SKIN ANTI-AGING: A SYSTEMATIC REVIEW AND META-ANALYSIS

Pu SY, Huang YL, Pu CM, Kang YN, Hoang KD, Chen KH, Chen C. Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis. Nutrients. 2023 Apr 26;15(9):2080. doi: 10.3390/nu15092080. PMID: 37432180; PMCID: PMC10180699.

114 ORAL INTAKE OF SPECIFIC BIOACTIVE COLLAGEN PEPTIDES REDUCES SKIN WRINKLES AND INCREASES DERMAL MATRIX SYNTHESIS

Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol. 2014;27(3):113-9. doi: 10.1159/000355523. Epub 2013 Dec 24. PMID: 24401291.

Fakt nr 22: Wyniki badań wskazują, że peptydy VERISOL® redukują zmarszczki

Fakt nr 23: Badanie kliniczne potwierdza, że peptydy VERISOL® zwiększają elastyczność skóry

Fakt nr 24: Badanie kliniczne potwierdza, że peptydy VERISOL® zwiększają nawilżenie skóry

115 PURIFICATION AND CHARACTERIZATION OF AN ANTIOXIDATIVE PEPTIDE FROM ENZYMATIC HYDROLYSATE OF YELLOWFIN SOLE

JUN, Shin-Young, et al. Purification and characterization of an antioxidative peptide from enzymatic hydrolysate of yellowfin sole (Limanda aspera) frame protein. Eur Food Res Technol, 2004, 219: 20-26.

Fakt nr 43: Antyoksydacyjny potencjał hydrolizatu kolagenu rybiego

116 ISOLATION AND IDENTIFICATION OF ANTIOXIDATIVE PEPTIDES FROM PORCINE COLLAGEN HYDROLYSATE BY CONSECUTIVE CHROMATOGRAPHY AND ELECTROSPRAY IONIZATION–MASS SPECTROMETRY

LI, Bo, et al. Isolation and identification of antioxidative peptides from porcine collagen hydrolysate by consecutive chromatography and electrospray ionization–mass spectrometry. Food chemistry, 2007, 102.4: 1135-1143.

117 THE PROTECTIVE EFFECTS OF LONG-TERM ORAL ADMINISTRATION OF MARINE COLLAGEN HYDROLYSATE FROM CHUM SALMON ON COLLAGEN MATRIX HOMEOSTASIS IN THE CHRONOLOGICAL AGED SKIN OF SPRAGUE-DAWLEY MALE RATS

Liang J, Pei X, Zhang Z, Wang N, Wang J, Li Y. The protective effects of long-term oral administration of marine collagen hydrolysate from chum salmon on collagen matrix homeostasis in the chronological aged skin of Sprague-Dawley male rats. J Food Sci. 2010 Oct;75(8):H230-8. doi: 10.1111/j.1750-3841.2010.01782.x. Epub 2010 Sep 24. PMID: 21535500.

118 DAILY CONSUMPTION OF THE COLLAGEN SUPPLEMENT PURE GOLD COLLAGEN® REDUCES VISIBLE SIGNS OF AGING

Borumand M, Sibilla S. Daily consumption of the collagen supplement Pure Gold Collagen® reduces visible signs of aging. Clin Interv Aging. 2014 Oct 13;9:1747-58. doi: 10.2147/CIA.S65939. Erratum in: Clin Interv Aging. 2020 Feb 04;15:131. PMID: 25342893; PMCID: PMC4206255.

119 A NEW VIEW CONCERNING THE EVECTS OF COLLAGEN HYDROLYSATE INTAKE ON SKIN PROPERTIES

Zague V. A new view concerning the effects of collagen hydrolysate intake on skin properties. Arch Dermatol Res. 2008 Oct;300(9):479-83. doi: 10.1007/s00403-008-0888-4. Epub 2008 Sep 11. PMID: 18784933.

120 SKIN ANTIAGEING AND SYSTEMIC REDOX EFFECTS OF SUPPLEMENTATION WITH MARINE COLLAGEN PEPTIDES AND PLANT-DERIVED ANTIOXIDANTS: A SINGLE-BLIND CASE-CONTROL CLINICAL STUDY

De Luca C, Mikhal’chik EV, Suprun MV, Papacharalambous M, Truhanov AI, Korkina LG. Skin Antiageing and Systemic Redox Effects of Supplementation with Marine Collagen Peptides and Plant-Derived Antioxidants: A Single-Blind Case-Control Clinical Study. Oxid Med Cell Longev. 2016;2016:4389410. doi: 10.1155/2016/4389410. Epub 2016 Jan 19. PMID: 26904164; PMCID: PMC4745978.

121 MARINE COLLAGEN AND ITS DERIVATIVES: VERSATILE AND SUSTAINABLE BIO-RESOURCES FOR HEALTHCARE

Salvatore L, Gallo N, Natali ML, Campa L, Lunetti P, Madaghiele M, Blasi FS, Corallo A, Capobianco L, Sannino A. Marine collagen and its derivatives: Versatile and sustainable bio-resources for healthcare. Mater Sci Eng C Mater Biol Appl. 2020 Aug;113:110963. doi: 10.1016/j.msec.2020.110963. Epub 2020 Apr 17. PMID: 32487384.

122 FREE RADICALS AND AGING

Barja G. Free radicals and aging. Trends Neurosci. 2004 Oct;27(10):595-600. doi: 10.1016/j.tins.2004.07.005. PMID: 15374670.

123 COLLAGEN STRUCTURE AND STABILITY

Shoulders MD, Raines RT. Collagen structure and stability. Annu Rev Biochem. 2009;78:929-58. doi: 10.1146/annurev.biochem.77.032207.120833. PMID: 19344236; PMCID: PMC2846778.

124 EFFECT OF COLLAGEN HYDROLYSATE IN ARTICULAR PAIN: A 6-MONTH RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED STUDY

Bruyère O, et al. Effect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study. Complement Ther Med (2012), doi:10.1016/j.ctim.2011.12.007

125 COLLAGEN PEPTIDES IMPROVE KNEE OSTEOARTHRITIS IN ELDERLY WOMEN: A 6-MONTH RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

JIANG, Jian-Xin, et al. Collagen peptides improve knee osteoarthritis in elderly women: A 6-month randomized, double blind, placebo-controlled study. Agro Food Industry Hi Tech, 2014, 25.2: 19-23.

126 EFFECTS OF PRO-HYP, A COLLAGEN HYDROLYSATE-DERIVED PEPTIDE, ON HYALURONIC ACID SYNTHESIS USING IN VITRO CULTURED SYNOVIUM CELLS AND ORAL INGESTION OF COLLAGEN HYDROLYSATES IN A GUINEA PIG MODEL OF OSTEOARTHRITIS

Ohara H, Iida H, Ito K, Takeuchi Y, Nomura Y. Effects of Pro-Hyp, a collagen hydrolysate-derived peptide, on hyaluronic acid synthesis using in vitro cultured synovium cells and oral ingestion of collagen hydrolysates in a guinea pig model of osteoarthritis. Biosci Biotechnol Biochem. 2010;74(10):2096-9.

Fakt nr 6: Można aktywować komórki produkujące kolagen, elastynę i kwas hialuronowy w skórze

127 TRANSPORT OF A TRIPEPTIDE, GLY-PRO-HYP, ACROSS THE PORCINE INTESTINAL BRUSH-BORDER MEMBRANE

Aito-Inoue M, Lackeyram D, Fan MZ, Sato K, Mine Y. Transport of a tripeptide, Gly-Pro-Hyp, across the porcine intestinal brush-border membrane. J Pept Sci. 2007 Jul;13(7):468-74     

128 ORAL COLLAGEN-DERIVED DIPEPTIDES, PROLYL-HYDROXYPROLINE AND HYDROXYPROLYL-GLYCINE, AMELIORATE SKIN BARRIER DYSFUNCTION AND ALTER GENE EXPRESSION PROFILES IN THE SKIN

Shimizu J, Asami N, Kataoka A, Sugihara F, Inoue N, Kimira Y, Wada M, Mano H. Oral collagen-derived dipeptides, prolyl-hydroxyproline and hydroxyprolyl-glycine, ameliorate skin barrier dysfunction and alter gene expression profiles in the skin. Biochem Biophys Res Commun. 2015 Jan 9;456(2):626-30. 

Fakt nr 41: Wpływ dipeptydów pochodzących z kolagenu na funkcje bariery skóry

129 HYDROLYZED COLLAGEN IMPROVES BONE METABOLISM AND BIOMECHANICAL PARAMETERS IN OVARIECTOMIZED MICE: AN IN VITRO AND IN VIVO STUDY

Guillerminet F, Beaupied H, Fabien-Soulé V, Tomé D, Benhamou CL, Roux C, Blais A. Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study. Bone. 2010 Mar;46(3):827-34.

130 EFFECT OF LOW DOSE TYPE I FISH COLLAGEN PEPTIDES COMBINED OR NOT WITH SILICON ON SKIN AGING SIGNS IN MATURE WOMEN

DUTEIL, Luc, et al. Effect of low dose type I fish collagen peptides combined or not with silicon on skin aging signs in mature women. JOJ Case Stud, 2018, 6.4: 001-005.

Fakt nr 14: Krzem wspiera syntezę kolagenu

131 DIET-INDUCED OBESITY AND ASSOCIATED DISORDERS ARE PREVENTED BY NATURAL BIOACTIVE TYPE 1 FISH COLLAGEN PEPTIDES (NATICOL®) TREATMENT

Astre G, Deleruyelle S, Dortignac A, Bonnet C, Valet P, Dray C. Diet-induced obesity and associated disorders are prevented by natural bioactive type 1 fish collagen peptides (Naticol®) treatment. J Physiol Biochem. 2018 Nov;74(4):647-654. doi: 10.1007/s13105-018-0650-0. Epub 2018 Sep 19. PMID: 30232707.

Fakt nr 17: Peptydy kolagenowe mogą zmniejszać konsekwencje otyłości

132 NON-TARGETED AND TARGETED ANALYSIS OF COLLAGEN HYDROLYSATES DURING THE COURSE OF DIGESTION AND ABSORPTION

Kleinnijenhuis AJ, van Holthoon FL, Maathuis AJH, Vanhoecke B, Prawitt J, Wauquier F, Wittrant Y. Non-targeted and targeted analysis of collagen hydrolysates during the course of digestion and absorption. Anal Bioanal Chem. 2020 Feb;412(4):973-982. doi: 10.1007/s00216-019-02323-x. Epub 2019 Dec 24. PMID: 31872275; PMCID: PMC7005076.

Fakt nr 40: Kwas żołądkowy i enzymy trawienne a hydrolizat kolagenu

133 EFFECTS OF HYDROLYZED COLLAGEN SUPPLEMENTATION ON SKIN AGING: A SYSTEMATIC REVIEW AND META-ANALYSIS

de Miranda RB, Weimer P, Rossi RC. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Int J Dermatol. 2021 Dec;60(12):1449-1461. doi: 10.1111/ijd.15518. Epub 2021 Mar 20. PMID: 33742704.

Fakt nr 28: Skuteczność hydrolizatu kolagenu jest potwierdzona badaniami klinicznymi, skuteczność liofilizatu kolagenu nie jest potwierdzona

134 EFFECT OF AN ORAL NUTRITION SUPPLEMENT CONTAINING COLLAGEN PEPTIDES ON STRATUM CORNEUM HYDRATION AND SKIN ELASTICITY IN HOSPITALIZED OLDER ADULTS: A MULTICENTER OPEN-LABEL RANDOMIZED CONTROLLED STUDY

Nomoto T, Iizaka S. Effect of an Oral Nutrition Supplement Containing Collagen Peptides on Stratum Corneum Hydration and Skin Elasticity in Hospitalized Older Adults: A Multicenter Open-label Randomized Controlled Study. Adv Skin Wound Care. 2020 Apr;33(4):186-191. doi: 10.1097/01.ASW.0000655492.40898.55. PMID: 32195722; PMCID: PMC7328867.

Fakt nr 28: Skuteczność hydrolizatu kolagenu jest potwierdzona badaniami klinicznymi, skuteczność liofilizatu kolagenu nie jest potwierdzona

135 A NUTRITIONAL SUPPLEMENT BLEND OF COLLAGEN PEPTIDES, LUTEIN AND WHEAT LIPID EXTRACT IMPROVES SKIN ATTRIBUTES

Shelly N H, Steve M W, Russell G, Dale K, Robert O’D, et al. A Nutritional Supplement Blend of Collagen Peptides, Lutein and Wheat Lipid Extract Improves Skin Attributes. JOJ Dermatol & Cosmet. 2021; 4(2): 555633. DOI: 10.19080/JOJDC.2021.04.555633

Fakt nr 61: Wpływ luteiny na komórki fibroblastów skórnych

136 ANTI-AGING EFFECTS OF LOW MOLECULAR WEIGHT COLLAGEN PEPTIDES SUPPLEMENTATION ON FACIAL WRINKLES AND SKIN HYDRATION: OUTCOMES FROM A SIXWEEK RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

Carrillo-Norte, J.A.; García-Mir, B.; Quintana, L.; Buracchio, B.; Guerrero-Bonmatty, R. Anti-Aging Effects of Low-Molecular-Weight Collagen Peptide Supplementation on Facial Wrinkles and Skin Hydration: Outcomes from a Six-Week Randomized, Double-Blind, Placebo-Controlled Trial. Cosmetics 2024, 11, 137.

137 ABSORPTION OF BIOACTIVE PEPTIDES FOLLOWING COLLAGEN HYDROLYSATE INTAKE: A RANDOMIZED, DOUBLE-BLIND CROSSOVER STUDY IN HEALTHY INDIVIDUALS

Virgilio N, Schön C, Mödinger Y, van der Steen B, Vleminckx S, van Holthoon FL, Kleinnijenhuis AJ, Silva CIF and Prawitt J (2024) Absorption of bioactive peptides following collagen hydrolysate intake: a randomized, double-blind crossover study in healthy individuals. Front. Nutr. 11:1416643. doi: 10.3389/fnut.2024.1416643

138 MARINE COLLAGEN AS A SOURCE OF BIOACTIVE MOLECULES – A REVIEW

ALEMÁN, Ailén; MARTÍNEZ-ALVAREZ, Oscar. Marine collagen as a source of bioactive molecules: A review. The Natural Products Journal, 2013, 3.2: 105-114.

139 HYALURONIC ACID: A KEY MOLECULE IN SKIN AGING

Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012 Jul 1;4(3):253-8. doi: 10.4161/derm.21923. PMID: 23467280; PMCID: PMC3583886.

Fakt nr 5: Między 25. a 50. rokiem życia ilość kwasu hialuronowego w skórze może obniżyć się o połowę

140 EXTRINSIC SKIN AGEING IN GERMAN, CHINESE AND JAPANESE WOMEN MANIFESTS DIFFERENTLY IN ALL THREE GROUPS DEPENDING ON ETHNIC BACKGROUND, AGE AND ANATOMICAL SITE

Vierkötter A, Hüls A, Yamamoto A, Stolz S, Krämer U, Matsui MS, Morita A, Wang S, Li Z, Jin L, Krutmann J, Schikowski T. Extrinsic skin ageing in German, Chinese and Japanese women manifests differently in all three groups depending on ethnic background, age and anatomical site. J Dermatol Sci. 2016 Sep;83(3):219-25. doi: 10.1016/j.jdermsci.2016.05.011. Epub 2016 May 24. PMID: 27289339.

141 HYALURONAN: METABOLISM AND FUNCTION

Kobayashi T, Chanmee T, Itano N. Hyaluronan: Metabolism and Function. Biomolecules. 2020 Nov 7;10(11):1525. doi: 10.3390/biom10111525. PMID: 33171800; PMCID: PMC7695009.

Fakt nr 5: Między 25. a 50. rokiem życia ilość kwasu hialuronowego w skórze może obniżyć się o połowę

142 TYPE I AND III COLLAGEN CONTENT AND FIBRE DISTRIBUTION IN NORMAL HUMAN SKIN DURING AGEING

Lovell CR, Smolenski KA, Duance VC, Light ND, Young S, Dyson M. Type I and III collagen content and fibre distribution in normal human skin during ageing. Br J Dermatol. 1987 Oct;117(4):419-28.

143 DECREASED COLLAGEN PRO- DUCTION IN CHRONOLOGICALLY AGED SKIN: ROLES OF AGE-DEPEN- DENT ALTERATION IN FIBROBLAST FUNCTION AND DEFECTIVE MECHANICAL STIMULATION

Varani J, Dame MK, Rittie L, Fligiel SE, Kang S, Fisher GJ, Voorhees JJ. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol. 2006 Jun;168(6):1861-8

Fakt nr 3: Organizm traci zdolności do uzupełniania kolagenu. Aż o ok. 1,5% rocznie!

144 SKIN HYDRATION: A REVIEW ON ITS MOLECULAR MECHANISMS

Verdier-Sévrain S, Bonté F. Skin hydration: a review on its molecular mechanisms. J Cosmet Dermatol. 2007 Jun;6(2):75-82. 

Fakt nr 5: Między 25. a 50. rokiem życia ilość kwasu hialuronowego w skórze może obniżyć się o połowę

145 TISSUE ELASTICITY AND THE AGEING ELASTIC FIBRE

Sherratt MJ. Tissue elasticity and the ageing elastic fibre. Age (Dordr). 2009 Dec;31(4):305-25. doi: 10.1007/s11357-009-9103-6. PMID: 19588272; PMCID: PMC2813052.

146 OVERALL SKIN TONE AND SKIN-LIGHTENING-IMPROVING EFFECTS WITH ORAL SUPPLEMENTATION OF LUTEIN AND ZEAXANTHIN ISOMERS: A DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL

Juturu V, Bowman JP, Deshpande J. Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial. Clin Cosmet Investig Dermatol. 2016 Oct 7;9:325-332. doi: 10.2147/CCID.S115519. PMID: 27785083; PMCID: PMC5063591.

Fakt nr 62: Wpływ przeciwutleniaczy z karotenoidami: luteiny i zeaksantyny na ludzką skórę

147 BENEFICIAL LONG-TERM EFFECTS OF COMBINED ORAL/TOPICAL ANTIOXIDANT TREATMENT WITH THE CAROTENOIDS LUTEIN AND ZEAXANTHIN ON HUMAN SKIN: A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

Palombo P, Fabrizi G, Ruocco V, Ruocco E, Fluhr J, Roberts R, Morganti P. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2007;20(4):199-210. doi: 10.1159/000101807. Epub 2007 Apr 19. PMID: 17446716.

Fakt nr 62: Wpływ przeciwutleniaczy z karotenoidami: luteiny i zeaksantyny na ludzką skórę

148 MOLECULAR EVIDENCE THAT ORAL SUPPLEMENTATION WITH LYCOPENE OR LUTEIN PROTECTS HUMAN SKIN AGAINST ULTRAVIOLET RADIATION: RESULTS FROM A DOUBLE-BLINDED, PLACEBO-CONTROLLED, CROSSOVER STUDY

Grether-Beck S, Marini A, Jaenicke T, Stahl W, Krutmann J. Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study. Br J Dermatol. 2017 May;176(5):1231-1240. doi: 10.1111/bjd.15080. Epub 2017 Mar 15. PMID: 27662341.

Fakt nr 11: Luteina to silny antyoksydant wspierający ochronę UVB/A i UVA1 w skórze

149 EFFECT OF AN ANTIOXIDANT SUPPLEMENT CONTAINING HIGH DOSE LUTEIN AND ZEAXANTHIN ON MACULAR PIGMENT AND SKIN CAROTENOID LEVELS

Obana A, Gohto Y, Nakazawa R, Moriyama T, Gellermann W, Bernstein PS. Effect of an antioxidant supplement containing high dose lutein and zeaxanthin on macular pigment and skin carotenoid levels. Sci Rep. 2020 Jun 24;10(1):10262. doi: 10.1038/s41598-020-66962-2. PMID: 32581313; PMCID: PMC7314813.

Fakt nr 62: Wpływ przeciwutleniaczy z karotenoidami: luteiny i zeaksantyny na ludzką skórę

150 BEAUTY FROM WITHIN: ORAL ADMINISTRATION OF A SULFUR-CONTAINING SUPPLEMENT METHYLSULFONYLMETHANE IMPROVES SIGNS OF SKIN AGEING

Muizzuddin N, Benjamin R. Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing. Int J Vitam Nutr Res. 2022 Jul;92(3-4):182-191. doi: 10.1024/0300-9831/a000643. Epub 2020 Feb 21. PMID: 32083522.

Fakt nr 49: MSM: siarka organiczna – właściwości

Fakt nr 50: Wpływ doustnej suplementacji MSM na skórę – opis badania

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